Nigella Sativa

 Nigella Sativa

1. Ahmad MF, Ahmad FA, Ashraf SA, et al. (2021) An updated knowledge of Black seed (Nigella sativa Linn.): Review of phytochemical constituents and pharmacological properties. J Herb Med. 25:100404. https://pubmed.ncbi.nlm.nih.gov/32983848

2. Ijaz H, Tulain UR, Qureshi J, et al. (2017) Review: Nigella sativa (Prophetic Medicine): A Review. Pak J Pharm Sci. 30:229-234. https://pubmed.ncbi.nlm.nih.gov/28603137

3. Maideen NMP (2020) Prophetic Medicine-Nigella Sativa (Black cumin seeds) - Potential herb for COVID-19? J Pharmacopuncture. 23:62-70. https://pubmed.ncbi.nlm.nih.gov/32685234

4. Sahebkar A, Soranna D, Liu X, et al. (2016) A systematic review and meta-analysis of randomized controlled trials investigating the effects of supplementation with Nigella sativa (black seed) on blood pressure. J Hypertens. 34:2127-2135. https://pubmed.ncbi.nlm.nih.gov/27512971

5. Mousavi SM, Sheikhi A, Varkaneh HK, et al. (2018) Effect of Nigella sativa supplementation on obesity indices: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med. 38:48-57. https://pubmed.ncbi.nlm.nih.gov/29857879

6. Amin F, Islam N, Anila N, Gilani AH. (2015) Clinical efficacy of the co-administration of Turmeric and Black seeds (Kalongi) in metabolic syndrome - a double blind randomized controlled trial - TAK-MetS trial. Complement Ther Med. 23:165-174. https://pubmed.ncbi.nlm.nih.gov/25847554

7. Askari G, Rouhani MH, Ghaedi E, et al. (2019) Effect of Nigella sativa (black seed) supplementation on glycemic control: A systematic review and meta-analysis of clinical trials. Phytother Res. 33:1341-1352. https://pubmed.ncbi.nlm.nih.gov/30873688

8. Mostafa TM, Hegazy SK, Elnaidany SS, et al. (2021) Nigella sativa as a promising intervention for metabolic and inflammatory disorders in obese prediabetic subjects: A comparative study of Nigella sativa versus both lifestyle modification and metformin. J Diabetes Complications 35:107947. https://pubmed.ncbi.nlm.nih.gov/34006388

9. Razmpoosh E, Safi S, Abdollahi N, et al. (2020) The effect of Nigella sativa on the measures of liver and kidney parameters: A systematic review and meta-analysis of randomized-controlled trials. Pharmacol Res. 156:104767. https://pubmed.ncbi.nlm.nih.gov/32201245

10. Tang G, Zhang L, Tao J, Wei Z. (2021) Effect of Nigella sativa in the treatment of nonalcoholic fatty liver disease: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 35:4183-4193. https://pubmed.ncbi.nlm.nih.gov/33728708

11. Khonche A, Huseini HF, Gholamian M, et al. (2019) Standardized Nigella sativa seed oil ameliorates hepatic steatosis, aminotransferase and lipid levels in non-alcoholic fatty liver disease: A randomized, double-blind and placebo-controlled clinical trial. J Ethnopharmacol. 234:106-111. https://pubmed.ncbi.nlm.nih.gov/30639231

12. Montazeri RS, Fatahi S, Sohouli MH, et al. (2021) The effect of nigella sativa on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials. J Food Biochem. 45:e13625. https://pubmed.ncbi.nlm.nih.gov/33559935

13. Emamat H, Mousavi SH, Kargar Shouraki J, et al. (2022) The effect of Nigella sativa oil on vascular dysfunction assessed by flow-mediated dilation and vascular-related biomarkers in subject with cardiovascular disease risk factors: A randomized controlled trial. Phytother Res. 36:2236-2245. https://pubmed.ncbi.nlm.nih.gov/35412685

14. Badar A, Kaatabi H, Bamosa A, (2017) Al-Elq A, Abou-Hozaifa B, Lebda F, Alkhadra A, Al-Almaie S. Effect of Nigella sativa supplementation over a one-year period on lipid levels, blood pressure and heart rate in type-2 diabetic patients receiving oral hypoglycemic agents: nonrandomized clinical trial. Ann Saudi Med. 37:56-63. https://pubmed.ncbi.nlm.nih.gov/28151458

15. Ansari ZM, Nasiruddin M, Khan RA, Haque SF (2017) Protective role of Nigella sativa in diabetic nephropathy: A randomized clinical trial. Saudi J Kidney Dis Transpl. 28:9-14. https://pubmed.ncbi.nlm.nih.gov/28098097

16. Alam MA, Nasiruddin M, Haque SF, Khan RA. (2020) Evaluation of safety and efficacy profile of Nigella sativa oil as an add-on therapy, in addition to alpha-keto analogue of essential amino acids in patients with chronic kidney disease. Saudi J Kidney Dis Transpl. 31:21-31. https://pubmed.ncbi.nlm.nih.gov/32129194

17. Ardakani Movaghati MR, Yousefi M, Saghebi SA, et al. (2019) Efficacy of black seed (Nigella sativa L.) on kidney stone dissolution: A randomized, double-blind, placebo-controlled, clinical trial. Phytother Res. 33:1404-1412. https://pubmed.ncbi.nlm.nih.gov/30873671

18. Farhangi MA, Dehghan P, Tajmiri S, Abbasi MM. (20106) The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) - 1, Nesfatin-1 and anthropometric features in patients with Hashimoto's thyroiditis: a randomized controlled trial. BMC Complement Altern Med. 16:471. https://pubmed.ncbi.nlm.nih.gov/27852303

19. Gheita TA, Kenawy SA. (2012) Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study. Phytother Res. 26:1246-8. https://pubmed.ncbi.nlm.nih.gov/22162258

20. Nikkhah-Bodaghi M, Darabi Z, Agah S, Hekmatdoost A. (2019) The effects of Nigella sativa on quality of life, disease activity index, and some of inflammatory and oxidative stress factors in patients with ulcerative colitis. Phytother Res. 33:1027-1032. https://pubmed.ncbi.nlm.nih.gov/30666747

21. Ahmed Jawad H, Ibraheem Azhar Y, Al-Hamdi Khalil I (2014) Evaluation of efficacy, safety and antioxidant effect of Nigella sativa in patients with psoriasis: A randomized clinical trial. Journal of Clinical and Experimental Investigations. 5:186-193. https://un.uobasrah.edu.iq/papers/4104.pdf

22. Ghorbanibirgani A, Khalili A, Rokhafrooz D. (2014) Comparing Nigella sativa Oil and Fish Oil in Treatment of Vitiligo. Iran Red Crescent Med J. 16:e4515. https://pubmed.ncbi.nlm.nih.gov/25068060

23. Yousefi M, Barikbin B, Kamalinejad M, et al. (2013) Comparison of therapeutic effect of topical Nigella with Betamethasone and Eucerin in hand eczema. J Eur Acad Dermatol Venereol. 27:1498-1504. https://pubmed.ncbi.nlm.nih.gov/23198836

24. Saad A, Besher S, Ammar N, Emam, H (2001) Therapeutic effects of Nigella Sativa on occupational contact dermatitis. Central European J Occ and Env Med. 7:26-38. https://www.researchgate.net/profile/Amal-Saad-Hussein/publication/230838076_THERAPEUTIC_EFFECTS_OF_NIGELLA_SATIVA_ON_OCCUPATIONAL_CONTACT_DERMATITIS/links/0912f5051cf358aed8000000/THERAPEUTIC-EFFECTS-OF-NIGELLA-SATIVA-ON-OCCUPATIONAL-CONTACT-DERMATITIS.p

25. Soleymani S, Zargaran A, Farzaei MH, et al. (2020) The effect of a hydrogel made by Nigella sativa L. on acne vulgaris: A randomized double-blind clinical trial. Phytother Res. 34:3052-3062. https://pubmed.ncbi.nlm.nih.gov/32548864

26. Han A, Shi D. (2021) The efficacy of Nigella sativa supplementation for asthma control: a meta-analysis of randomized controlled studies. Postepy Dermatol Alergol. 38:561-565. https://pubmed.ncbi.nlm.nih.gov/34658694

27. Boskabady MH, Farhadi J. (2008) The possible prophylactic effect of Nigella sativa seed aqueous extract on respiratory symptoms and pulmonary function tests on chemical war victims: a randomized, double-blind, placebo-controlled trial. J Altern Complement Med. 14:1137-1144. https://pubmed.ncbi.nlm.nih.gov/18991514

28. Nikakhlagh S, Rahim F, Aryani FH, et al. (2011) Herbal treatment of allergic rhinitis: the use of Nigella sativa. Am J Otolaryngol. 32:402-407. https://pubmed.ncbi.nlm.nih.gov/20947211

29. Kalus U, Pruss A, Bystron J, et al. (2003) Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytother Res. 17:1209-1214. https://pubmed.ncbi.nlm.nih.gov/14669258

30. Huseini HF, Mohtashami R, Sadeghzadeh E, et al. (2022) Efficacy and safety of oral Nigella sativa oil for symptomatic treatment of knee osteoarthritis: A double-blind, randomized, placebo-controlled clinical trial. Complement Ther Clin Pract. 49:101666. https://pubmed.ncbi.nlm.nih.gov/36150238

31. Azizi F, Ghorat F, Rakhshani MH, Rad M (2019) Comparison of the effect of topical use of Nigella Sativa oil and diclofenac gel on osteoarthritis pain in older people: A randomized, double-blind, clinical trial. J Herb Med. 16:100529. https://www.sciencedirect.com/science/article/abs/pii/S2210803319300053

32. Huseini HF, Kianbakht S, Mirshamsi MH, Zarch AB. (2016) Effectiveness of Topical Nigella sativa Seed Oil in the Treatment of Cyclic Mastalgia: A Randomized, Triple-Blind, Active, and Placebo-Controlled Clinical Trial. Planta Med. 82:285-288. https://pubmed.ncbi.nlm.nih.gov/26584456

33. Molaie M, Darvishi B, Jafari Azar Z, et al. (2019) Effects of a combination of Nigella sativa and Vitex agnus-castus with citalopram on healthy menopausal women with hot flashes: results from a subpopulation analysis. Gynecol Endocrinol. 35:58-61. https://pubmed.ncbi.nlm.nih.gov/30129806

34. Naeimi SA, Tansaz M, Hajimehdipoor H, Saber S (2020) Comparing the Effect of Nigella sativa oil Soft Gel and Placebo on Oligomenorrhea, Amenorrhea and Laboratory Characteristics in Patients with Polycystic Ovarian Syndrome, a Randomized Clinical Trial. Res J Pharmacogn. (RJP) 7:49-58. https://www.rjpharmacognosy.ir/article_99289_f5613bb45b6fb6dd8a7a2a9b5f7857a1.pdf

35. Bin Sayeed MS, Shams T, Fahim Hossain S, et al. (2014) Nigella sativa L. seeds modulate mood, anxiety and cognition in healthy adolescent males. J Ethnopharmacol. 152:156-162. https://pubmed.ncbi.nlm.nih.gov/24412554

36. Zadeh AR, Eghbal AF, Mirghazanfari SM, et al. (2022) Nigella sativa extract in the treatment of depression and serum Brain-Derived Neurotrophic Factor (BDNF) levels. J Res Med Sci. 27:28. https://pubmed.ncbi.nlm.nih.gov/35548175

37. Bin Sayeed MS, Asaduzzaman M, Morshed H, et al. (2013) The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers. J Ethnopharmacol. 148:780-786. https://pubmed.ncbi.nlm.nih.gov/23707331

38. Akhondian J, Parsa A, Rakhshande H. (2007) The effect of Nigella sativa L. (black cumin seed) on intractable pediatric seizures. Med Sci Monit. 13:CR555-9. 4 https://pubmed.ncbi.nlm.nih.gov/18049435

39. Akhondian J, Kianifar H, Raoofziaee M, et al. (2011) The effect of thymoquinone on intractable pediatric seizures (pilot study). Epilepsy Res. 93:39-43. https://pubmed.ncbi.nlm.nih.gov/21112742

40. Oysu C, Tosun A, Yilmaz HB, et al. (2014) Topical Nigella Sativa for nasal symptoms in elderly. Auris Nasus Larynx. 41:269-272. https://pubmed.ncbi.nlm.nih.gov/24398317

41. Pipalia PR, Annigeri RG, Mehta R. (2016) Clinicobiochemical evaluation of turmeric with black pepper and nigella sativa in management of oral submucous fibrosis-a double-blind, randomized preliminary study. Oral Surg Oral Med Oral Pathol Oral Radiol. 122:705-712. https://pubmed.ncbi.nlm.nih.gov/27720650

42. Khan ZA, Prabhu N, Ahmed N, et al. (2022) A Comparative Study on Alvogyl and a Mixture of Black Seed Oil and Powder for Alveolar Osteitis: A Randomized Double-Blind Controlled Clinical Trial. Int J Clin Pract. 2022:7756226. https://pubmed.ncbi.nlm.nih.gov/35685605

43. Sadat Afraz E, Kazemi S, Ghaneei F, et al. (2022) The Healing Effects of Nigella sativa Gel on Oral Traumatic Ulcer. Int J BioLife Sci. 1:118. https://www.jobiost.com/article_162053.html

44. Rahman I, Mohammed A, AlSheddi MA, et al. (2023) Nigella sativa oil as a treatment for gingivitis: A randomized active-control trial. Asian Pac J Trop Med. 16:129-1138. https://www.apjtm.org/text.asp?2023/16/3/129/372290

45. Mohan ME, Thomas JV, Mohan MC, et al. (2023) A proprietary black cumin oil extract (Nigella sativa) (BlaQmax(r)) modulates stress-sleep-immunity axis safely: Randomized double-blind placebo-controlled study. Front Nutr. 10:1152680. https://pubmed.ncbi.nlm.nih.gov/37139438

46. Alavinejad P, Aghadhani M, Bakhtiari N, et al. (2023) Evaluation of total black seed (Nigella sativa) extract efficacy in patients with irritable bowel syndrome - pilot study. Eur. Chem. Bull. 12:997-1006. https://www.eurchembull.com/uploads/paper/85fcfba8ff6ae017bd08ff7823739390.pdf

47. Alizadeh A, Mohammah-Alizadeh-Charandabi S, Khodaie L, Mirghafourvand M. (2023) Effect of Nigella sativa L. seed oil on urinary incontinence and quality of life in menopausal women: A triple-blind randomized controlled trial. Phytother Res. 37:2012-2023. https://pubmed.ncbi.nlm.nih.gov/36640148

48. Kolahdooz M, Nasri S, Modarres SZ, et al. (2014) Effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men: a randomized, double-blind, placebo-controlled clinical trial. Phytomedicine. 21:901-905. https://pubmed.ncbi.nlm.nih.gov/24680621

49. Amalia A, Hendarto H, Mustika A, Susanti I (2022) Effects of Nigella Sativa on Female Infertility: A Systematic Review. Proc 6th Int Conf Med Health Inform. May 2022, 234-237. https://dl.acm.org/doi/abs/10.1145/3545729.3545776

50. Zakaria R, Astuti SCD (2022) The Effect of Black Cumin (Nigella Sativa) on Breastfeeding Mothers. J Info Kesehatan 20:29-40. https://jurnal.poltekeskupang.ac.id/index.php/infokes/article/view/627/437

51. Nemati S, Masroorchehr M, Elahi H, et al. (2021) Effects of Nigella sativa Extract on Chronic Rhinosinusitis: A Randomized Double Blind Study. Indian J Otolaryngol Head Neck Surg. 73:455-460. https://pubmed.ncbi.nlm.nih.gov/34722227

52. Bashar T, Misbahuddin M, Hossain MA. (2014) A double-blind, randomize, placebo-control trial to evaluate the effect of Nigella sativa on palmar arsenical keratosis patients. Bangladesh J Pharmacol. 9:15-21. http://www.bdpsjournal.org/index.php/bjp/article/view/188/611

53. Salem A, Bamosa A, Alam M, et al. (2021) Effect of Nigella sativa on general health and immune system in young healthy volunteers; a randomized, placebo-controlled, double-blinded clinical trial. F1000Research 10:1199 https://f1000research.com/articles/10-1199

54. Behnamfar N, Parsa Yekta Z, Mojab F, Kazem Naeini SM. (2019) The effect of nigella sativa oil on the prevention of phlebitis induced by chemotherapy: a clinical trial. Biomedicine (Taipei). 9:20. https://pubmed.ncbi.nlm.nih.gov/31453801

55. Hussain SA, Mohammed Ameen HA, Mohammed MO, et al. (2019) Nigella sativa Oil Mouth Rinse Improves Chemotherapy-Induced Oral Mucositis in Patients with Acute Myeloid Leukemia. Biomed Res Int. 2019:3619357. https://pubmed.ncbi.nlm.nih.gov/31781612

56. Rafati M, Ghasemi A, Saeedi M, et al. (2019) Nigella sativa L. for prevention of acute radiation dermatitis in breast cancer: A randomized, double-blind, placebo-controlled, clinical trial. Complement Ther Med. 47:102205. https://pubmed.ncbi.nlm.nih.gov/31780017

57. Mousa HFM, Abd-El-Fatah NK, Darwish OA, et al. (2017) Effect of Nigella sativa seed administration on prevention of febrile neutropenia during chemotherapy among children with brain tumors. Childs Nerv Syst. 33:793-800. https://pubmed.ncbi.nlm.nih.gov/28349493

58. Barakat EM, El Wakeel LM, Hagag RS. (2013) Effects of Nigella sativa on outcome of hepatitis C in Egypt. World J Gastroenterol. 19:2529-2536. https://pubmed.ncbi.nlm.nih.gov/23674855

59. Ahmed S, Zahoor A, Ibrahim M, et al. (2020) Enhanced Efficacy of Direct-Acting Antivirals in Hepatitis C Patients by Coadministration of Black Cumin and Ascorbate as Antioxidant Adjuvants. Oxid Med Cell Longev. 2020:7087921. https://pubmed.ncbi.nlm.nih.gov/32566096

60. Adiban Fard F, Tork Zahrani S, Akbarzadeh Bagheban A, Mojab F. (2015) Therapeutic Effects of Nigella Sativa Linn (Black Cumin) on Candida albicans Vaginitis. Arch Clin Infect Dis. 10:e22991. https://brieflands.com/articles/archcid-20960.pdf

61. Hashem-Dabaghian F, Agah S, Taghavi-Shirazi M, Ghobadi A. (2016) Combination of Nigella sativa and Honey in Eradication of Gastric Helicobacter pylori Infection. Iran Red Crescent Med J. 18:e23771. https://pubmed.ncbi.nlm.nih.gov/28191328

62. Alizadeh-Naini M, Yousefnejad H, Hejazi N. (2020) The beneficial health effects of Nigella sativa on Helicobacter pylori eradication, dyspepsia symptoms, and quality of life in infected patients: A pilot study. Phytother Res. 34:1367-1376. https://pubmed.ncbi.nlm.nih.gov/31916648

63. Mohtashami R, Huseini HF, Heydari M, et al. (2015) Efficacy and safety of honey based formulation of Nigella sativa seed oil in functional dyspepsia: A double blind randomized controlled clinical trial. J Ethnopharmacol. 175:147-52. https://pubmed.ncbi.nlm.nih.gov/26386381

64. Babu B, Rao P, Suman E, Udayalaxmi J (2023) A Study of Antibacterial Effect of Nigella Sativa Seed Extracts on Bacterial Isolates from Cases of Wound Infection. Infect Disord Drug Targets. 2023 Apr 3. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/37016531

65. Rafati S, Niakan M, Naseri M. (2014) Anti-microbial effect of Nigella sativa seed extract against staphylococcal skin Infection. Med J Islam Repub Iran. 28:42. https://pubmed.ncbi.nlm.nih.gov/25405108

66. Hannan A, Saleem S, Chaudhary S, et al. (2008) Anti bacterial activity of Nigella sativa against clinical isolates of methicillin resistant Staphylococcus aureus. J Ayub Med Coll Abbottabad. 20:72-74. https://pubmed.ncbi.nlm.nih.gov/19610522

67. Liaqat F, Sheikh AA, Nazir J, et al. (2015) Report-Isolation identification and control of vancomycin resistant Staphylococcus aureus. Pak J Pharm Sci. 28:997-1004. https://pubmed.ncbi.nlm.nih.gov/26004734

68. Elango A, Rao LN, Sugumar P, Radhakrishnan A. (2022) Evaluation of Clinical Efficacy and Safety of Nigella Sativa Seed Oil added to Standard Treatment in Uncomplicated Respiratory Infection - A Randomised, Open Labelled, and Parallel Arm Study. Special Issue - COVID-19 & Other Communicable Diseases 91-97. https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/815/702

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71. Al-Haidari KAA, Faiq TAN, Ghareeb OA (2021) Preventive value of black seed in people at risk of infection with COVID-19. Pak J Med Health Sci. 15:384-387. https://pjmhsonline.com/2021/jan/384.pdf

72. Ashraf S, Ashraf S, Ashraf M, et al. (2023) DOCTORS LOUNGE consortium.(2023) Honey and Nigella sativa against COVID-19 in Pakistan (HNS-COVID-PK): A multicenter placebo-controlled randomized clinical trial. Phytother Res. 37:627-644. https://pubmed.ncbi.nlm.nih.gov/36420866

73. Ashraf S, Ashraf S, Ashraf M, et al. (2020) Honey and Nigella sativa against COVID-19 in Pakistan (HNS-COVID-PK): A multi-center placebo-controlled randomized clinical trial. medRxiv preprint, Nov 2020. https://www.medrxiv.org/content/10.1101/2020.10.30.20217364v4.full.pdf

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76. Al-Haidari KAA, Faiq TN, Ghareeb OA (2021) Clinical trial of black seeds against covid - 19 in Kirkuk city/Iraq. Indian J Foren Med Toxicol 15:3393-3399. https://www.revistaamplamente.com/index.php/ijfmt/article/view/15825

77. Koshak AE, Koshak EA, Mobeireek AF, et al. (2021) Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial. Complement Ther Med. 61:102769. https://pubmed.ncbi.nlm.nih.gov/34407441

78. Said SA, Abdulbaset A, El-Kholy AA, et al. (2022) The effect of Nigella sativa and vitamin D3 supplementation on the clinical outcome in COVID-19 patients: A randomized controlled clinical trial. Front Pharmacol. 13:1011522. https://pubmed.ncbi.nlm.nih.gov/36425571

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